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Outcomes of Other Prescription drugs on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (major route) and CYP2C9 (minor route). Therefore, inhibitors of those isoenzymes may lessen sildenafil clearance and inducers of such isoenzymes may well raise sildenafil clearance.Sildenafil is also sometimes made use of to deal with pulmonary h